Klise ear therapy 118 ml.(ndr)

cliche® Ear Therapy

Natural Otic Cleansing Solution, with Antimicrobial and Soothing Activity
for the Advanced Care and Maintenance of the Ear Canal in Dogs

Features
Natural protection based on
Hamamelis and Tea Tree.
Fortified with Chlorhexidine to
prevent chronic otitis.
Prevents and eliminates the accumulation of wax.
Antimicrobial and antifungal effect –
Helps prevent otitis.
Soothing Action – Reduces itching
or discomfort.
Pre-medication cleaning for
maximize the effectiveness of the antibiotic /
antifungal.
Suitable for frequent use –
Indicated for the daily hygiene of
ear canals and pinnae
headphones.
Versatile: cleans, deodorizes, protects.
Effective and very safe. Not fit for your
use in cats.
Colorless aqueous solution – No
stains household surfaces or fabrics.

La ear cleaning It is a routine that we must
perform on our dogs to guarantee the hygiene of the
ear canal and avoid the appearance of otitis externa, one of the
the most common diseases in dogs
To perform a correct cleaning of the ear, you must use
appropriate washing solutions and avoid the use of products
with antibiotics or anti-inflammatories, reserving them for
when there is a pathology. In the case of animals with
otitis, it is necessary to use a cleaner prior to the topical antibiotic/antifungal for it to act more effectively.
Composition:

Properties and Mechanism of Action:
cliche® Ear Therapy is a natural otic cleaning solution, water-based, with
antimicrobial and soothing for the advanced care and maintenance of the ear canal in dogs from
twelve weeks old.
Due to its advanced formula and its properties, it can be used as a cleaner for frequent use on the
daily hygiene of healthy ear canals and, also, as a cleaner and coadjuvant treatment in
bacterial or fungal otitis.
• El hamamelis (Hamamelis virginiana) It is a shrub native to the humid forests of eastern
North America (Canada and United States). Witch hazel leaves contain a high
percentage of tannins and flavonoids. It has been used traditionally for its astringent properties,
vasoconstrictor and anti-inflammatory. The astringent effect of the tannins promotes a
healing and antihemorrhagic. It has been observed that the witch hazel extract is capable of inhibiting in
live some enzymes that contribute to the breakdown of connective tissue (when the
activity of these enzymes, vascular integrity is compromised). The anti-inflammatory effect
it seems to be related to the inhibition of mediators involved in inflammatory processes.
In addition, it contains other natural compounds such as proanthocyanins that give it properties
antioxidants. A study demonstrated the benefits of applying witch hazel to skin with eczema, by
observed a reduction in inflammation and associated pruritus.
• El tea tree (Melaleuca alternifolia) He is originally from Australia. Its oil has been used for many
years for its antiseptic and anti-inflammatory properties and can currently be found in the
market in numerous products for prophylactic and therapeutic purposes. Its oil can be extracted
of the leaves, branches and stem.
Regarding its antibacterial activity, it seems that this is due to a direct action on the double
phospholipid layer of the bacteria, generating an increase in the permeability of the cell wall and
the loss of cellular structures involved in energy production processes and in
the synthesis of structural components (Kim et al., 1995). Various studies have shown its
effectiveness in dermatological problems and as a mouthwash, reducing the number of
microorganisms and associated clinical signs. Some in vitro studies show that olive oil
Tea tree can be a good alternative to antifungals such as ketoconazole for the treatment of
gender infections Malassezia (Hammer et al. 2000). It has also been evaluated, with results
favourable, its effect in vivo for the treatment of superficial fungal infections such as
oral yeast infection (Jandourek et al., 1998) or onychomycosis (Buck et al., 1994). have not been reported
evidence of the emergence of resistance despite the widespread use of the product in Australia since the 1920s. • The chlorhexidine It is a disinfectant that is used for the treatment of environmental surfaces and, in
less concentrated forms, for the treatment of the skin, ears and oral cavity. was discovered
at the end of 1940 and later its antiseptic action on skin was discovered (Haugen & Johansen,
1974). It has a broad spectrum of action on both bacteria and fungi. Has activity against
gram positive and negative bacteria with some exceptions. The antiseptic activity of chlorhexidine
It is due to its action on the cell membrane. Produces a change in membrane permeability
and, consequently, causes protein precipitation, alterations of the osmotic balance and the
normal cell metabolism (Star et al., 2003). Widely used for its rapid effect and its good
residual activity once applied. Dermal absorption is minimal, so there is a low risk of
systemic toxicity. It is not irritating and hypersensitivity reactions are very rare. Some
Studies have shown that long-term treatment with chlorhexidine does not significantly increase
the appearance of bacterial resistance or the appearance of opportunistic infections.
Indications:
• Cleaner for the daily care and maintenance of the hygienic and physiological conditions of the canal.
auditory.
• Antiseptic agent for the preventive maintenance of bacterial otitis.
• Antiseptic agent for preventive maintenance of fungal otitis.
• Cleaner prior to treatment with topical antibiotics and/or antifungals.
• Helps reduce itching or discomfort associated with otitis.
• Prevention of recurrent chronic otitis.
• Ideal for ulcerated or inflamed mucosa.
Target species: Dog older than 12 weeks of age.
Directions:
• Fill the ear canal with the product: apply between 1-5 ml depending on the race.
• Gently but firmly massage the base of the ear for several seconds.
• Allow the pet to shake its head.
• Carefully wipe excess solution from inside the ears with gauze or other material.
not abrasive.
✓ For maintenance apply 1-2 times a week.
✓ Suitable for frequent use.
Safety: cliche® Ear Theraphy is a very soft, non-irritating solution, even on the mucosa or canal.
sensitive or irritated epithelial
cliche® Ear Therapy can be used on dogs of any breed from twelve weeks of age.
Cats may be more susceptible to tea tree oil poisoning after
topical application than other species, due to its grooming behavior. However, the risk of ingestion
it is significantly reduced when the application is in the ear. However, and although the tea tree does not
is excessively toxic when ingested, KLISE® Ear Therapy is not suitable for use on cats. It has been
seen that tea tree oil (Melaleuca alternifolia) it is not irritating even when used in
concentrations up to 10% (Altmann, 1991) O 25% (Southwell et al., 1997) on healthy skin.
Warnings: Not for use in cats. Avoid contact with the eyes. Keep the container well
closed, in a cool, dry place, protected from sunlight and out of the reach and sight of children and
animals.
Presentation: 118 ml. Bibliography:
• Australian Standard as 2782-85. Oil of Melaleuca, terpinen-4-ol type. 1995. In: Altman, PM Australian tea tree oil –
a natural antiseptic. Aust. J. Biotech., v. 3, no. 4, p. 247-248, 1989.
• Bernard P, Balansard P, Balansard G, et al. Venitonic pharmacodynamic value of galenic preparations with a base
of hamamelis leaves. J Pharm Belgium.
• Brown TR, Ehrlich CE, Stehman FB, et al. A clinical evaluation of chlorhexidine gluconate spray as compared with
iodophor scrub for preoperative skin preparation. Surg Ginecol & Obstet, v.158, p.363-366, 1984.
• Carson CF, Hammer KA, Riley TV In Vitro Activities of Ketoconazole, Econazole, Miconazole, and Melaleuca
alternifolia (Tea Tree) Oil against Malassezia Species.
• Carson CF, Hammer KA, Riley TV Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other
Medicinal Properties. Clin Microb Reviews. Jan. 2006, p. 50-62.
• Davies RM, Hull PS Plaque inhibition and distribution of chlorhexidine in beagle dogs. J Periodontal Res Suppl.
1973; 12: 22-7.
• Disinfectants and preservatives. In: Parfitt E, ed. Martindale: the complete drug reference. 32nd ed. London:
Pharmaceutical Press; 1999 .p.1097-127.
• Duwiejua M, Zeitlin IJ, Waterman PG, et al. Anti-inflammatory activity of Polygonum bistorta, Guaiacum officinale
and Hamamelis virginiana in rats. J Pharm Pharmacol. 1994;46:286-290.
• Font E. Antiseptics and Disinfectants. Pharmaceutical field. Health Education, February 2001.
• Hammer KA, Carson CF, Riley TV Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on
Candida albicans, Candida glabrata and Saccharomyces cerevisiae. Journal of Antimicrobial Chemotherapy, no. 53,
2004. p. 1081-1085.
• Hammer KA, Carson CF, Riley TV In vitro activity of Melaleuca alternifolia (tea tree) oil against dermathophytes
and other filamentous fungi. Journal of Antimicrobial Chemotherapy, n.50. 2002. p.195-199.
• Korting HC, Schafer-Korting M, Hart H, et al. Anti-inflammatory activity of witch hazel distillate applied topically to
the skin. Eur J Clin Pharmacol. 1993;44:315-8.
• Korting HC, Schafer-Korting M, Klovekorn W, et al. Comparative efficacy of hamamelis distallate and hydrocortisone cream in atopic eczema. Eur J Clin Pharmacol. 1995;48:461-465.
• Larson E. Apic guidelines for use of topical antimicrobial agents. Am J Infect Control v.16, p.253-266, 1988.
• Papadopoulos CJ, Carson CF, Hammer KA, Riley TV Susceptibility of Pseudomonas to Melaleuca alternifolia
(tea tree) oil and components. Journal of Antimicrobial Chemotherapy, no. 58, 2006. p. 449-451.
• Perapoch J, Salcedo S, Gallart A, Peguero G, Casellas M, Barroso C, et al. Umbilical colonization in newborn
normal born. Comparative study of four methods of umbilical antisepsis. An Esp Pediatr 1993; 39:195-8.
• Sanchez RI, Swain SF, Nusbaum KE, et al. Effects of chlorhexidine diacetate and povidone-iodine on wound
healing in dogs. Vet Surg, v.17, n.6, p.291-295, 1998.
• Swaim SF, Lee AH Topical wound medications: A review. J Am Vet Med Assoc, v.190, n.12, p.1588-1593, 1987.
• Swoboda M, Meurer J. Treatment of atopic dermatitis with hamamelis ointment. Br J Phytother. 1991;2:128-132.
•Winrow MJ. Metabolic studies with radiolabeled chlorhexidine in animals and man. J Periodontal Res Suppl.
1973; 12: 45-8.
If you are interested in any of the items listed, please do not hesitate to request them through the following contacts:
[email protected], 918 440 273 or your VetNova Technical-Commercial Representative.

See technical sheet