Prilben vet 5 mg 14 tablets | treatment of heart failure in dogs

PRILBEN VET 5mg 

FILM COATED FOR DOGS AND CATS
Beige bicovex oblong divisible film-coated tablets
Laboratory
KARIZOO
Pharmaceutical form
Oral tablet (Comp.o.)
Composition by tablet:
Benazepril 4,6 mg (equivalent to 5 mg benazepril hydrochloride). Excipients: Dioxide of
titanium (E171) 1,929 mg; yellow iron oxide (E172) 0,117 mg; red iron oxide (E172) 0,014
mg; black iron oxide (E172) 0,004 mg.
Pharmacological properties
Benazepril hydrochloride is a hydrolyzed prodrug in vivo to benazeprilat, which inhibits the
angiotensin-converting enzyme (ACE), thus preventing the conversion of angiotensin I
inactive to active angiotensin II. Therefore, benazeprilat inhibits all effects induced by
angiotensin II, particularly arterial and venous vasoconstriction and sodium and water retention by
the kidneys. Benazepril hydrochloride causes prolonged inhibition of plasma ACE in the
dog, which persisted significantly for 24 hours after a single dose. In
In dogs with heart failure, benazepril hydrochloride reduces peripheral resistance and
blood pressure and left ventricular load.
After oral administration, benazepril is rapidly absorbed from the gastrointestinal tract.
A part of absorbed benazepril is hydrolyzed by hepatic enzymes to the active substance,
benazeprilat, the rest, is metabolized into hydrolyzed compounds or subsists as benazepril
unchanged. The absolute systemic bioavailability, calculated for oral benazepril vs.
intravenous benazepril is approximately 9%. The peak concentration of benazeprilat is
reached in approximately 2 hours, both in a fasting situation and taking food. He
benazepril and benazeprilat is predominantly bound to plasma proteins. the
Repeated administration leads to a slight accumulation of benazeprilat in the plasma, which
it reaches steady state in less than 4 days. In dogs, the majority of benazeprilat is
It is rapidly eliminated, and it is excreted in the same proportion through the liver and urine. after the
administration of a single dose of the product (0,23 mg benazepril/kg bw), the peak of
concentration of benazeprilat (Cmax of 40,9 ng/ml) around time 1,5h (Tmax of 1,5h), with
an AUC of 320,5 ng/ml/h and a half-life (t 1/2 ) of 12,4 h.
Interactions and incompatibilities
Concomitant administration with potassium-sparing diuretics should be considered, and
To perform this, it is recommended to monitor plasmatic potassium levels. The combination of this
product with other antihypertensive agents (eg calcium channel blockers, â blockers
or diuretics), anesthetics or sedatives may lead to additional hypotensive effects. in it
man, the combination of ACE inhibitors with NSAIDs may reduce the efficacy
anti-hypertensive or impair renal function. Therefore, one should carefully study the
concurrent use of this product with NSAIDs or drugs with a hypotensive effect.
Indications and target species
Treatment of congestive heart failure in dogs weighing more than 5 kg.

Treatment of chronic renal failure in cats. There are no studies in cats less than 2,5 kg.
Contraindications
• Do not use in case of hypersensitivity to inhibitors of converting enzymes.
angiotensin or any other ingredient,
• Do not use in dogs with heart failure as a result of aortic stenosis.
efectos secundarios
Some dogs may show transient signs of fatigue. At the beginning of treatment it can
a drop in blood pressure occurs. Benazepril hydrochloride may increase
plasma creatinine concentrations.
Route of administration
Orally.
Posology
Dogs: The dose is 0,23 mg benazepril/kg bw and day, which corresponds to 0,25 mg benazepril hydrochloride
benazepril/kg bw and day. It should be administered orally once a day, with meals or outside of
they. This dose corresponds to 1 tablet per 20 kg, according to the following table:

• If considered clinically necessary and advised by a veterinarian, the dose can be doubled.
  (maintaining a single take).
  Cats: the dose is 0,46 mg benazepril/ kg bw/ day, which corresponds to 0,50 mg benazepril hydrochloride
  benazepril/ kg bw at meals or outside of them. This dose corresponds:

Wait time
Not applicable.
conservation mode
Do not store at temperatures above 25 °C. Store in a dry place.
Presentation
Boxes with:
1 blister (14 tablets).
10 blisters (140 tablets).
Reg No.
1844-ENG

Data sheet 

prilben