Ganadexil enro 5% 250 ml | antibiotic injectable solution

GANADEXYL

GANADEXYL® ENROFLOXACIN 5% Injectable solution Antibacterialin injectable solution
Laboratory
VETERINARY INDUSTRIAL, SA – INVESA
Pharmaceutical form
Injectable solution (Sol.i.)
Composition:
Enrofloxacin 50mg; benzyl alcohol 10 mg.
Pharmacological properties
Enrofloxacin is an antibiotic that belongs to the chemical class of fluoroquinolones. The compound exerts a bactericidal activity through a mechanism of action based on the inhibition of subunit A of bacterial DNA gyrase (Topoisomerase II), preventing negative axial rotation of the DNA molecule.
Enrofloxacin exerts its antimicrobial action at low concentrations, against most Gram (-) and many Gram (+) bacteria, both aerobic and anaerobic.
Antibacterial spectrum: Staphylococcus spp., Bordetella bronchiseptica, Escherichia coli, Enterobacter spp., Proteus spp., Salmonella spp., Pseudomonas spp., Streptococcus spp., pasteurella spp., Mycoplasma spp., Enterococcus spp., Actinobacillus pleuropneumoniae. Gram (-) enteric bacilli.
Enrofloxacin has relatively high IM and SC bioavailability in almost all species studied.
In cattle, after IM administration of 5 mg/kg, a maximum concentration of 1 µg/ml is observed, which is maintained for more than 6 h. The volume of distribution is equal to 0,6 l/kg, the plasmatic elimination half-life is equal to 2 h. and clearance equal to 210 ml/kg/h.
Interactions and incompatibilities
• In dogs and cats, antagonistic effects may occur in joint administration with chloramphenicol, macrolides or tetracyclines.
• In dogs, do not use simultaneously with theophylline.
• Do not apply simultaneously with non-steroidal anti-inflammatory drugs (convulsions may occur).
• Hepatic interactions may appear with other hepatic elimination drugs.
Indications and target species
Cattle (Calves):
• Respiratory tract infections: bronchopneumonia, pasteurellosis and mycoplasmosis.
• Gastrointestinal tract infections: Diarrhea caused by colibacillus, colibacillosis and colisepticemia.
Porcine: Treatment of piglet diarrhea, diarrhea and enterotoxemia caused by E. coli y Salmonella spp. and MMA syndrome.
Dogs: Treatment of infections of the respiratory and digestive organs, of the urinary system and of the skin produced by microorganisms sensitive to enrofloxacin.
• The use of this product must be restricted to those cases in which the bacteria are resistant to other antibiotics; A bacteriological confirmation of the diagnosis and a sensitivity test of the bacteria causing the process will be carried out prior to its use.
• If there is no improvement within three days of starting therapy, a change in the chosen therapy may be indicated.
Contraindications
• Animals with cartilage growth disorders should not be treated.
• Exclude from treatment dogs and cats under 12 months of age in small and medium breeds, and 18 months of age in large breeds, or that have not completed their growth phase.
• Dogs with a clinical history of epilepsy and GABA-related nervous disorders will also be excluded.

GANADEXYL

efectos secundarios
No secondary effects derived from the administration of the specialty in the target species for which it is indicated have been reported. However, like other fluoroquinolones, enrofloxacin has a damaging action on the joints, especially in young animals. Consequently, care must be taken to ensure that the administration of enrofloxacin is adequate, without excessively increasing the dose or treatment time.
• In dogs and calves, gastrointestinal disorders may occasionally occur.
• After administration, the specialty can produce an irritant effect at the injection site, although this disappears spontaneously after 4-5 days.
Route of administration
Intramuscular or subcutaneous.
Posology
Cattle (Calves): 0,5-1 ml (equivalent to 25-50 mg of enrofloxacin)/10 kg of bw every day for 3 days. Continue treatment for up to 5 days in the case of salmonellosis or severe infections. subcutaneous route. Do not apply more than 10 ml at the same injection point.
Porcine: 0,5-1 ml (equivalent to 25-50 mg of enrofloxacin)/10 kg of bw every day for 3 days. Continue treatment for up to 5 days in the case of salmonellosis or serious infections. Intramuscular route. Do not apply more than 2,5 ml at the same injection site.
Dogs: 0,1 ml (equivalent to 5 mg of enrofloxacin)/kg of bw every day for 5 days. subcutaneous route. If no clinical improvement is observed in 3 days, reconsider the treatment.
• To ensure a correct dosage, the weight of the animals must be determined.
Wait time
Meat: 14 days.
conservation mode
Keep at a temperature below 25 °C and protected from light.
Comments
Dispensation with veterinary prescription.
Presentation
100 ml and 250 ml containers.
Reg No.
0944 ESP

See technical sheet

GANADEXYL